One of the most common symptoms of hormone imbalance, including clinical hypogonadism (the medical term for low testosterone), hypothyroidism, and low estrogen, is chronic fatigue. To put that another way, low testosterone levels could be preventing you from seeing the progress in the gym you would be able to achieve if your body had a more optimum hormonal balance. You have probably already heard that testosterone, exercise (including weightlifting), and lean muscle production are inherently connected. You can also purchase over-the-counter (OTC) products marketed as testosterone supplements or boosters. Read on to learn more about potential causes of low testosterone and to get the details on testosterone boosters and how they might affect your sex drive. If you are unsure or have any questions about testosterone replacement therapy, ask your doctor. If you are taking hormone replacement therapy, regular follow-up appointments with your doctor are important. In general, testosterone replacement therapy is safe. Sign up for HEALTHBeat and receive trusted health information delivered right to your inbox. Get the latest in health news delivered to your inbox! Additionally, stress can impact your mood, potentially leading to anxiety and depression, both of which can reduce your interest in sex. If you’re having an unusually difficult time losing excess weight or you’re having trouble maintaining your weight despite proper eating and exercise, hormone imbalances like Low T might be the culprit. TRT is not appropriate for men (or women) who do not have a low testosterone issue and only want to increase their results in the gym. That being said, the sweat equity invested (in terms of time and energy invested into workouts) pays a much higher dividend with optimal testosterone levels relative to those that are deficient. Low testosterone is a hindrance to exercise or body building that is nearly impossible to overcome without appropriate medical guidance. Specifically, testosterone, along with anti-Müllerian hormone (AMH) promote growth of the Wolffian duct and degeneration of the Müllerian duct respectively. Both testosterone and DHT bind to an androgen receptor; however, DHT has a stronger binding affinity than testosterone and may have more androgenic effect in certain tissues at lower levels. Testosterone can either directly exert effects on target tissues or be metabolized by 5α-reductase into dihydrotestosterone (DHT) or aromatized to estradiol (E2). In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. If you have sleep apnea or are concerned you may have symptoms of this condition, talk with your doctor about treatment options. The largest improvements are seen with moderate- or high-intensity resistance exercises involving large muscle groups, such as squats and bench presses. Primary hypogonadism happens when your testicles aren’t making normal levels of testosterone. Healthcare providers consider testosterone levels below 300 nanograms per deciliter (ng/dL) as low in adults. Low testosterone (male hypogonadism) is a condition in which your testicles don’t produce enough testosterone.