Shahiduzzaman, M., Dyachenko, V., Khalafalla, R. E., Desouky, A. Y., and Daugschies, A. Effects of curcumin on Cryptosporidium parvum in vitro. Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S., Gil, A., and Quiles, J. L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Fang, X. D., Yang, F., Zhu, L., Shen, Y. L., Wang, L. L., and Chen, Y. Y. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. And Singh, S. K. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., Choi, H., Min, J. S., Kim, Y. S., Yoon, S. W., and Ahn, J. K. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. And Shen, L. Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., and Srinivas, P. S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Ranjan, D., Siquijor, A., Johnston, T. D., Wu, G., and Nagabhuskahn, M. The effect of curcumin on human B-cell immortalization by Epstein-Barr virus. Mehta, K., Pantazis, P., McQueen, T., and Aggarwal, B. B. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Kuo, M. L., Huang, T. S., and Lin, J. K. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Oetari, S., Sudibyo, M., Commandeur, J. N., Samhoedi, R., and Vermeulen, N. P. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Srivastava, K. C., Bordia, A., and Verma, S. K. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Srinivasan, M. Effect of curcumin on blood sugar as seen in a diabetic subject. Lantz, R. C., Chen, G. J., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of turmeric extracts on inflammatory mediator production. Yuan, K., Weng, Q., Zhang, H., Xiong, J., and Xu, G. Application of capillary zone electrophoresis in the separation and determination of the curcuminoids in urine. Determination of curcumin in urine by capillary electrophoresis. And Bhide, S. V. Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Rukkumani, R., Aruna, K., Varma, P. S., and Menon, V. P. Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Chand S, Hair C, Beswick L. A rare case of turmeric-induced hepatotoxicity. Imam Z, Khasawneh M, Jomaa D, Iftikhar H, Sayedahmad Z. Drug induced liver injury attributed to a curcumin supplement. Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. The effects of a traditional drug, tumeric (Curcuma longa), and placebo on the healing of duodenal ulcer. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. And Kanwar, M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Zhang, M., Deng, C., Zheng, J., Xia, J., and Sheng, D. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. However, no estrogenic agonistic, androgenic agonistic, and estrogenic antagonistic potential of CDC was observed below 100 μM (Table 2).Figure 6Full size imageAndrogenic antagonistic activity of β-cyclodextrin–curcumin. The IC50 values of flutamide and CDC were 1.05 × 10–5 M and 7.00 × 10–8 M, respectively. Similarly, the CDC played an excellent role in increasing testosterone secretion ranging from 0.2 to 25 μM (Fig. 2), and 5 μM CDC showed the highest effect on testosterone secretion. The positive cells were stained in dark blue color. (A) 3β-HSD staining of purified rat Leydig cells (located in 4 mL scale). Therefore, the subsequent experiments were performed in concentrations ranging from 0.1 to 25 μM.
